Occurrence of acute pulmonary embolism induced by recombinant erythropoietin during treatment of pure red cell aplasia associated with thymoma
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چکیده
منابع مشابه
Pure red cell aplasia and associated thymoma
Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, su...
متن کاملThymoma associated with hypogammaglobulinaemia and pure red cell aplasia
Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, hypogammaglobulinaemia, pancytopaenia, collagen diseases, and, most commonly, myasthenia gravis. The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of ...
متن کاملPure Red Cell Aplasia Induced by Antibodies against Human Recombinant Erythropoietin
Human recombinant erythropoietin (epoetin) is a very effective and safe biopharmaceutical. However, in 1998 the incidence of pure red cell aplasia (PRCA) induced by antierythropoietin (anti-EPO) antibodies in patients treated with epoetin started to increase. PRCA is a rare condition of non-regenerative anemia which can be associated with a variety of diseases and is in some cases of immunologi...
متن کاملInvasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia
We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 104/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythro...
متن کاملAnti-erythropoietin antibody-mediated pure red cell aplasia after treatment with recombinant erythropoietin products: recommendations for minimization of risk.
Since 1998, there has been a marked increase in incidence of pure red cell aplasia secondary to development of anti-erythropoietin antibodies (Ab+ PRCA) in patients who have chronic kidney disease (CKD) and receive recombinant erythropoietin. The relationship between incidence of Ab+ PRCA and specific erythropoietin products has not been examined rigorously. Manufacturers provided data regardin...
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ژورنال
عنوان ژورنال: Medicine
سال: 2019
ISSN: 0025-7974,1536-5964
DOI: 10.1097/md.0000000000014789